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螺旋藻中的肽类分子或具有分明的降血压效应
更新日期: 2019-01-28 作者: Carrizzo A等 文章泉源:Hypertension
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克日,一项登载在国际杂志Hypertension(《高血压》)上的研讨陈诉中,来自罗马大学等机构的迷信家们经过研讨表现,从螺旋藻中提取出的一种肽类或能经过扩张血管来抵挡高血压,相干研讨后果无望协助研讨职员前期开辟出医治高血压的新型疗法。

现在,螺旋藻因具有多种无益效应而被越来越多的人以为是超等食品,但现在研讨职员并不清晰螺旋藻在机体中的作用机制,螺旋藻的学名为钝顶节旋藻(Arthrospira platensis),其是一种能停止光协作用的蓝细菌,偶然候其被归类为蓝藻,并且被以为是阿兹特克人(Aztecs)的食品。

这项研讨中,研讨者发明,一种来自螺旋藻中的提取物或能经过扩张血管来无效中和动脉高血压。研讨职员经过研讨从螺旋藻中别离出了一种肽类(由氨基酸构成的特别分子),当在实行室中对离体的动脉和植物模子停止研讨后他们发明,这种肽类可以扩张动脉血管,从而发生抗高血压的效应。

研讨者Albino Carrizzo表现,我们起首模仿螺旋藻提取物在机体中的消化进程,换句话说,我们可以再现摄入这种肽类物质先人类机体肠道所发作的改动,如许研讨职员就可以别离出被机体所吸取的肽类分子。研讨职员起首辨别出了一种名为SP6的肽类分子,当在实行室中将SP6赐与离体的血管后,该分子就能发生一种血管舒张的效应,而这便是一种潜伏的抗高血压的效应,随后研讨者将SP6赐与高血压植物模子,后果发明,SP6可以发生一种降血压的反响。

研讨者指出,高血压患者通常会在经过一氧化氮调理血管内壁反响的天然进程中存在缺陷,而我们从螺旋藻中别离出的肽类分子则可以发扬一种积极性的作用,前期研讨职员还需求停止更为深化的研讨来说明SP6肽类分子的详细作用机制,研讨者以为,SP6大概能作为罕见药物的一种自然佐剂来协助改进高血压患者的血管内皮功用,从而无效控制患者的高血压。(泉源:生物谷Bioon.com

 

Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism

 

Abstract  Considered as a superfood of the future, Spirulina platensis matrix has been extensively used because of its beneficial effect on the management of cardiovascular diseases. However, its nutraceutical properties, bioactive compounds, and molecular mechanisms are unknown. Here, we demonstrate that S platensis matrix processed in vitro by simulated gastrointestinal digestion induces direct endothelial nitric oxide (NO)-mediated vasorelaxation of resistance vessels in mice. To gain insight into the bioactive compounds responsible for this effect, we used a complex multistep peptidomic approach to fractionate the crude digest: of the 5 peptide fractions identified (A-E), only fraction E evoked vasorelaxation. High-resolution mass spectrometry-based screening revealed in E the presence of 4 main peptides (SP3-SP6 [spirulina peptides]), of which only SP6 (GIVAGDVTPI) exerted direct endothelium-dependent vasodilation of ex vivo vessels, an effect occurring via a PI3K (phosphoinositide-3-kinase)/AKT (serine/threonine kinase Akt) pathway converging on NO release. In vivo, administration of SP6 evoked a significant hemodynamic effect, reducing blood pressure, an action absent in eNOS (endothelial NO synthase)-de?cient mice. Of note, although lower doses of SP6 had no hemodynamic effects, it still enhanced endothelial NO vasorelaxation. Finally, in an experimental model of arterial hypertension, SP6 exerted an antihypertensive effect, improving endothelial vasorelaxation associated with enhanced serum nitrite levels. Based on our results, this novel decameric peptide may extend the possible fields of application for spirulina-derived peptides and could be developed into a promising nonpharmacological approach for the containment of pathologies associated with vascular NO misregulation.

 

原文链接:https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11801


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